BeWo 细胞模型及其在胎盘转运机制研究中的应用(7)
Application of BeWo cell model in studies on placental transport mechanism
GUO Jie， SONG Dian-rong*
(The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medince， Tianjin 300150， China)
[Abstract] As placenta barrier controls material exchanges between mother and fetus during pregnancy， studies on the placental transport mechanism of drugs is of great importance to analyze the efficacy， safety and toxicity of drugs. BeWo cells are derived from human choriocarcinomas， which can form monolayer trophoblast cells to offers an efficient placenta barrier in vitro for estimating nutrient and drug intake， efflux and transport. This essay focuses on the establishment and characteristics of BeWo cell model， and the advance on studies on nutrient and drug intake， efflux and transport mechanism by applying the model.
[Key words] BeWo cell model； placenta barrier； transporter； transport mechanism； trophoblast cell
doi：10.4268/cjcmm20122107
[责任编辑 陈玲]
[稿件编号] 20120304007
[基金项目] 教育部博士点基金项目(200900001234)；天津市卫生局科研基金项目(09KZ118)
[通信作者] *宋殿荣，Tel：(022)60335423，E-mail：songdr58@126.com
[作者简介] 郭洁，研究方向为妊娠期应用中药的安全性评价，E-mail：guojie76@126.com, 百拇医药(郭洁 宋殿荣)
GUO Jie， SONG Dian-rong*
(The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medince， Tianjin 300150， China)
[Abstract] As placenta barrier controls material exchanges between mother and fetus during pregnancy， studies on the placental transport mechanism of drugs is of great importance to analyze the efficacy， safety and toxicity of drugs. BeWo cells are derived from human choriocarcinomas， which can form monolayer trophoblast cells to offers an efficient placenta barrier in vitro for estimating nutrient and drug intake， efflux and transport. This essay focuses on the establishment and characteristics of BeWo cell model， and the advance on studies on nutrient and drug intake， efflux and transport mechanism by applying the model.
[Key words] BeWo cell model； placenta barrier； transporter； transport mechanism； trophoblast cell
doi：10.4268/cjcmm20122107
[责任编辑 陈玲]
[稿件编号] 20120304007
[基金项目] 教育部博士点基金项目(200900001234)；天津市卫生局科研基金项目(09KZ118)
[通信作者] *宋殿荣，Tel：(022)60335423，E-mail：songdr58@126.com
[作者简介] 郭洁，研究方向为妊娠期应用中药的安全性评价，E-mail：guojie76@126.com, 百拇医药(郭洁 宋殿荣)