苏木对红花中羟基红花黄色素A的药代动力学影响(3)
[9] Tian Y， Yang Z F， Li Y， et al. Pharmacokinetic comparisons of hydroxysafflower yellow A in normal and blood stasis syndrome rats[J]. J Ethnopharmacol， 2010， 129(1)： 1.
[10] 张海防， 郭健新， 黄罗生， 等. 羟基红花黄色素A 在大鼠体内的药代动力学[J]. 中国药科大学学报， 2006， 37(5)： 456.
Pharmacokinetic effect of Sappan Lignum on hydroxysafflor
yellow A in Carthami Flos
XIA Li1， CHEN Xiang-mei1， PENG Li-rong2， WANG Shi-xiang1， WANG Xiao-wen3，ZUO Yan3， ZHANG Peng3， LIU Qin-she1， 3， ZHENG Xiao-hui1， 4*
(1. College of Life Sciences， Northwest University， Xi′an 710069， China；
2. The Central Hospital of Xi′an， Xi′an 710086， China；
3. The People′s Hospital of Shanxi Province， Xi′an 710068， China；
4. Research Institute of Tsinghua University in Shenzhen， Shenzhen 518057， China)
[Abstract] Objective： To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos. Method： Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software. Result： In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility， HSYA showed a significant lower in apparent volumes of distribution of t1/2Ka ， t1/2αand V1/F， with slight advance in Tmax. Conclusion： Sappan Lignum can accelerate absorption， distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.
[Key words] Carthami Flos； Sappan Lignum； HSYA； pharmacokinetics
doi：10.4268/cjcmm20130224
[责任编辑 陈玲], 百拇医药(夏丽，陈向梅，彭莉蓉，王世祥，王晓雯，左燕，张鹏，刘勤社，郑晓晖)
[10] 张海防， 郭健新， 黄罗生， 等. 羟基红花黄色素A 在大鼠体内的药代动力学[J]. 中国药科大学学报， 2006， 37(5)： 456.
Pharmacokinetic effect of Sappan Lignum on hydroxysafflor
yellow A in Carthami Flos
XIA Li1， CHEN Xiang-mei1， PENG Li-rong2， WANG Shi-xiang1， WANG Xiao-wen3，ZUO Yan3， ZHANG Peng3， LIU Qin-she1， 3， ZHENG Xiao-hui1， 4*
(1. College of Life Sciences， Northwest University， Xi′an 710069， China；
2. The Central Hospital of Xi′an， Xi′an 710086， China；
3. The People′s Hospital of Shanxi Province， Xi′an 710068， China；
4. Research Institute of Tsinghua University in Shenzhen， Shenzhen 518057， China)
[Abstract] Objective： To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos. Method： Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software. Result： In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility， HSYA showed a significant lower in apparent volumes of distribution of t1/2Ka ， t1/2αand V1/F， with slight advance in Tmax. Conclusion： Sappan Lignum can accelerate absorption， distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.
[Key words] Carthami Flos； Sappan Lignum； HSYA； pharmacokinetics
doi：10.4268/cjcmm20130224
[责任编辑 陈玲], 百拇医药(夏丽，陈向梅，彭莉蓉，王世祥，王晓雯，左燕，张鹏，刘勤社，郑晓晖)