淫羊藿生品及不同炮制品小鼠药代动力学特征的比较研究(3)
Comparative study on effect of crude and different processed products of
epimedium on pharmacokinetics characteristics in mice
CUI Li1，2， SUN E1， QIAN Qian1， FAN Hong，wei3， ZOU Jian，jun3， JIA Xiao，bin1，2*
(1. Key Laboratory of Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional
Chinese Medicine， Jiangsu Provincial Academy of Traditional Chinese Medicine， Nanjing 210028， China；
2. College of Pharmacy of Nanjing University of Chinese Medicine， Nanjing 210046， China；
3. Clinical Pharmacology Laboratory， Nanjing First Hospital Affiliated to Nanjing Medical University， Nanjing 210006， China)
[Abstract]To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products， mice were orally administered with crude epimedium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator， the relationship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2.0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium， heated epimedium and crude epimedium， namely processed epimedium > heated epimedium > crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability， while epimedium processed with sheep oil could further promote in vivo absorption.
[Key words]epimedium； processing； pharmacokinetics； pharmacological effect method
doi：10.4268/cjcmm20131033, http://www.100md.com(崔莉 孙娥 钱浅 樊宏伟 邹建军 贾晓斌)
epimedium on pharmacokinetics characteristics in mice
CUI Li1，2， SUN E1， QIAN Qian1， FAN Hong，wei3， ZOU Jian，jun3， JIA Xiao，bin1，2*
(1. Key Laboratory of Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional
Chinese Medicine， Jiangsu Provincial Academy of Traditional Chinese Medicine， Nanjing 210028， China；
2. College of Pharmacy of Nanjing University of Chinese Medicine， Nanjing 210046， China；
3. Clinical Pharmacology Laboratory， Nanjing First Hospital Affiliated to Nanjing Medical University， Nanjing 210006， China)
[Abstract]To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products， mice were orally administered with crude epimedium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator， the relationship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2.0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium， heated epimedium and crude epimedium， namely processed epimedium > heated epimedium > crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability， while epimedium processed with sheep oil could further promote in vivo absorption.
[Key words]epimedium； processing； pharmacokinetics； pharmacological effect method
doi：10.4268/cjcmm20131033, http://www.100md.com(崔莉 孙娥 钱浅 樊宏伟 邹建军 贾晓斌)