共聚维酮辅助馨月舒喷雾干燥及其对粉体学性质的影响(3)
2.Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] To study the application characteristics of copovidone(PVP-S630) in Xinyueshu extracts during the spray drying process， and its effect on such pharmaceutical properties as micromeritics and drug release behavior. PVP-S630 was added into Xinyueshu extracts to study on the spray drying， the effect of different dosages of PVP-S630 against the wall sticking effect of the spray drying， as well as the power property of Xinyueshu spray drying power and the dissolution in vitro behavior of the effective component of hyperoside. The results showed that PVP-S630 revealed a significant anti-wall sticking effect， with no notable change in the grain size of the spray drying power， increase in the fluidity， improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior of hyperoside. It was worth further studying the application of PVP-S630 in spray drying power of traditional Chinese medicine.
[Key words] PVP-S630； spray drying； fluidity； dissolution in vitro
doi：10.4268/cjcmm20132315, 百拇医药(蒋艳荣 张振海 丁冬梅 严红梅 胡绍英 贾晓斌)
[Abstract] To study the application characteristics of copovidone(PVP-S630) in Xinyueshu extracts during the spray drying process， and its effect on such pharmaceutical properties as micromeritics and drug release behavior. PVP-S630 was added into Xinyueshu extracts to study on the spray drying， the effect of different dosages of PVP-S630 against the wall sticking effect of the spray drying， as well as the power property of Xinyueshu spray drying power and the dissolution in vitro behavior of the effective component of hyperoside. The results showed that PVP-S630 revealed a significant anti-wall sticking effect， with no notable change in the grain size of the spray drying power， increase in the fluidity， improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior of hyperoside. It was worth further studying the application of PVP-S630 in spray drying power of traditional Chinese medicine.
[Key words] PVP-S630； spray drying； fluidity； dissolution in vitro
doi：10.4268/cjcmm20132315, 百拇医药(蒋艳荣 张振海 丁冬梅 严红梅 胡绍英 贾晓斌)