[摘要]目的：优化选择光动力疗法在嫩肤中的治疗方案。方法：采用正交实验法，以5%、10%、20%的5-氨基酮戊酸药物外涂于光老化患者的上臂皮肤，封包时间分别为20min、30min、60min，然后给予80J/cm2的红光照射20min、40min、60min，观察其不良反应并选择最佳的嫩肤方案。结果：浓度为10%的5-氨基酮戊酸封包30min、照射20min的嫩肤疗效最佳，不良反应最小。结论：10% 5-氨基酮戊酸封包30min、照射20min的治疗方案在嫩肤中的疗效肯定，安全性大，值得临床推广使用。

    [关键词]皮肤光老化；光动力疗法；嫩肤；正交设计

    [中图分类号]R730.57[文献标识码]A[文章编号]1008-6455(2011)04-0621-03

    Optimization for the treatment of photodynamic rejuvenation

    LI Run-xiang，ZHU Hui-lan，LIANG Bi-hua，XIONG Si-ying

    (Guangzhou Institute of Dermatology and Denerology，Guangzhou 510095，Guangdong,China)

    Abstract：Objective Optimization of photodynamic therapy in the rejuvenation of the treatment.MethodsOrthogonal experiment to 5%、10%、 20% of 5-aminolevulinic acid drugs in patients treated with the upper arm in the light of aging skin,COnclusion time was 20 min,30min,60min later,the red to the 80J/cm2 irradiation 20min, 40min, 60min, adverse reactions were observed and choose the best skin rejuvenation program. ResultsThe concentration of 10% 5-aminolevulinic acid packets 30min, 20min of the rejuvenation effect of exposure to the best minimal adverse reactions. Conclusion 10% 5-aminolevulinic acid packets 30min,20min irradiation in the skin rejuvenation treatment programs in the effective and safe is great, worthy of clinical use. ......