【摘要】 目的 评价肝动脉化疗栓塞(TACE)结合三维适形放射治疗(3DCRT)对原发性肝癌(PHC)的效果。方法 对46例不能手术的原发性肝癌患者进行3DCRT治疗，单次剂量3.54～7 Gy，照射次数7～15次。结果 46例患者中，完全缓解率(CR)20.4%,部分缓解率(PR)39.5%,总有效率(CR+PR)为60.4%。1、2、3年生存率分别为59.2%、15.4%和10.1%。Cox多因素分析显示肿块>5em、等效生物剂量>60 Gy以及合并门静脉癌栓为影响生存率的主要因素。结论 TACE结合3D(1RT 治疗PHC能明显提高临床治疗效果。而毒副作用未见增加。

    【关键词】 原发性肝癌；化疗栓塞；三维适形放疗

    Three dimensional conformal radiation therapy combined with interventionaI therapy for primary hepatic carcinoma LI Ming-jie.The Central Hospital of Luohe,Luohe 462000,China

    【Abstract】 Objective It is to evaluate the effects of transcatheter arterial chemoembolization(TACE)combined with three dimensional conformal radiation therapy(3DCRT)for unresectable primary hepatic carcinoma(PHC).Methods 46 inoperable patients with hepatic cancer were treated by 3DCRT at 3.54～6-31 Gy once daily in 7 to 15 fractions.Results The complete response rate(fCR1 )was 20.4%,PR was 39.5%,theoverall response rate (CR+PR) was60.4%.The 1 ......