布地奈德联合硫酸特布他林吸入治疗儿童哮喘急性发作疗效观察
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2010年4月5日
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[摘要] 目的:观察布地奈德联合硫酸特布他林吸入治疗儿童哮喘急性发作的临床疗效。方法:选取2007年11月～2009年11月符合哮喘诊断标准的哮喘急性发作患儿92例,随机分为两组,对照组46例,予硫酸特布他林2.5 mg/次,q8h经空气压缩泵吸入,口服泼尼松龙2 mg/(kg·d),最大剂量为40 mg,治疗组46例,予布地奈德2 mg/次联合硫酸特布他林0.5 mg/次,q8h吸入治疗,疗程7 d。比较两组临床症状消失的时间及肺功能改善程度。结果:治疗组临床症状及肺部体征消失时间较对照组缩短,肺功能改善明显优于对照组。结论:布地奈德与硫酸特布他林联合治疗哮喘急性发作能迅速缓解临床症状、体征,改善肺功能,具有协同作用,且安全性高,值得临床推广应用。
[关键词] 布地奈德;硫酸特布他林;吸入;儿童;哮喘
[中图分类号] R562.2+5 [文献标识码]B [文章编号]1674-4721(2010)04(a)-049-02
Observation on efficacy of budesonide inhalation of terbutaline sulphate co-treatment of children with acute asthma attack
HUANG Xiaoyan
(Gongming Hospital,Guangdong Province, Shenzhen 518106, China)
[Abstract] Objective: To observe the clinical effects of budesonide unites terbutaline sulfate inspiration to treat the child asthma acute outbreak. Methods: To select from November, 2007 to conform to asthma to November, 2009 to diagnose the standard the asthma acute outbreak trouble 92 examples, divided into 2 groups stochastically, the control group 46 examples, gave terbutaline sulfate 2.5 mg/time,q8h after the air compression pump suction, took orally prednisolone 2 mg/(kg·d), highest 40 mg, the treatment group 46 examples, gave pulmicort respules 2 mg/time to unite bricanyl 0.5 mg/time, q8h inspiration treatment, the treatment course 7 days.Compared with two groups of clinical symptom vanishing time and lung function improvement degree. Results: The treatment group clinical symptom and the lungs symptom vanishing time compared the control group to reduce, the lung function improvement surpassed the control group obviously. Conclusion: Budesonide unites terbutaline sulphate treats the asthma acute outbreak to be able jointly to alleviate the clinical symptom, the symptom rapidly, improves the lung function, has the synergism, also the security is high, is worthy of clinical promoted application.
[Key words] Budesonide; Terbutaline sulphate; Inspiration; Child; Asthma
近30年来哮喘患病率及病死率明显上升,发病年龄逐渐减小,严重影响儿童的身心健康,也给家庭、社会带来沉重的精神和经济负担。儿童哮喘急性发作是儿科常见急症之一,主要表现为喘息、呼吸困难、胸闷、咳嗽。本院用布地奈德联合硫酸特布他林经空气压缩泵吸入治疗,取得较好的效果,现报道如下:
1资料与方法
1.1一般资料
选取2007年11月～2009年11月符合哮喘诊断标准的哮喘急性发作患儿92例,全部患儿均无呼吸衰竭、心力衰竭等并发症,并除外先天性心脏病、结核感染及支气管异物等疾病,将其随机分为两组,对照组46例,其中,男25例,女21例,年龄1.0～6.5岁,治疗组46例,其中,男28例,女18例,年龄10个月～6.5岁,两组年龄、性别、病情严重程度经统计学处理,差异无统计学意义,具有可比性。
1.2治疗方法
对照组予硫酸特布他林2.5 mg/次,加0.9% NaCl溶液至2 ml,每日3次,经空气压缩泵吸入,口服泼尼松龙2 mg/(kg·d),最大剂量为40 mg,每日1次。治疗组予布地奈德2 mg/次,联合硫酸特布他林2.5 mg/次,加0.9% NaCl溶液至2 ml,每日3次,经空气压缩泵吸入治疗,疗程7 d。
1.3疗效观察
观察治疗后患儿呼吸急促、咳嗽、喘息、哮鸣音等情况,并观察治疗前后肺功能(FEV1)情况。
1.4统计学处理
使用SPSS 12 ......
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