还原型谷胱甘肽治疗酒精性肝硬化的临床效果分析(1)
[摘要] 目的 探讨还原型谷胱甘肽治疗酒精性肝硬化的临床效果。 方法 将2012年1月～2014年6月本院收治的74例酒精性肝硬化患者平均分为实验组和对照组各37例，两组患者均给予复方甘草酸苷和肝胺常规治疗，实验组患者在常规治疗基础上静脉滴注还原型谷胱甘肽。比较两组患者的治疗效果，治疗前后患者肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBiL)、γ-谷氨酰转肽酶(GGT)]、肌纤维指标[透明质酸酶(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)]和凝血酶原时间(PT)的变化。 结果 实验组总有效率为94.59%，显著高于对照组的70.27%，差异有统计学意义(P<0.05)。治疗后，两组患者的ALT、AST、TBiL、GGT均下降，与治疗前比较，差异有统计学意义(P<0.05)，且实验组下降幅度显著优于对照组(P<0.05)。治疗后，两组患者的HA、PCⅢ、Ⅳ-C均下降，与治疗前比较，差异有统计学意义(P<0.05)，且实验组下降幅度显著优于对照组(P<0.05)。治疗后两组患者的PT与治疗前比较均显著降低(P<0.05)，且实验组PT显著短于对照组，差异有统计学意义(P<0.05)。 结论 还原型谷胱甘肽治疗酒精性肝硬化效果确切，可有效改善患者的临床症状和各项生理指标水平。
[关键词] 还原型谷胱甘肽；酒精性肝硬化；肝功能；疗效
[中图分类号] R657.3+1 [文献标识码] A [文章编号] 1674-4721(2015)01(b)-0098-03
The clinical effect of reduced glutathione in treatment of alcoholic cirrhosis
LV Fu-ming
Department of Gastroenterology，the Central Hospital of Xinxiang City in Henan Province，Xinxiang 453000，China
[Abstract] Objective To explore the clinical effect of reduced glutathione in the treatment of alcoholic cirrhosis. Methods 74 cases of patients with alcoholic cirrhosis from January 2012 to June 2014 in our hospital were equally divided into study group and control group.All patients were given with compound glycyrrhizin and gerontine.Patients in study group were given with reduced glutathione on the basis of routine treatment.The therapeutic effect，liver function [alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，total bilirubin (TBiL)，γ-glutamyl endopeptidase (GGT)]，hepatic fibrosis [hyaluronidase (HA)，Ⅲ procollagen (PCⅢ)，Ⅳ collagen (Ⅳ-C)] and prothrombin time (PT) was compared and analyzed before and after treatment. Results The total effective rate in study group was 94.59%，higher than 70.27% in the control group，the difference was significant (P<0.05).After treatment，the ALT，AST，TBiL，GGT in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05).The HA，PCⅢ，Ⅳ-C in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05).PT in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05). Conclusion Reduced glutathione has excellent effect in treating alcoholic cirrhosis，it can improve the clinical symptom and the level of physiological indicators observably.
[Key words] Reduced glutathione；Alcoholic cirrhosis；Liver function；Therapeutic effect (吕福鸣)
[关键词] 还原型谷胱甘肽；酒精性肝硬化；肝功能；疗效
[中图分类号] R657.3+1 [文献标识码] A [文章编号] 1674-4721(2015)01(b)-0098-03
The clinical effect of reduced glutathione in treatment of alcoholic cirrhosis
LV Fu-ming
Department of Gastroenterology，the Central Hospital of Xinxiang City in Henan Province，Xinxiang 453000，China
[Abstract] Objective To explore the clinical effect of reduced glutathione in the treatment of alcoholic cirrhosis. Methods 74 cases of patients with alcoholic cirrhosis from January 2012 to June 2014 in our hospital were equally divided into study group and control group.All patients were given with compound glycyrrhizin and gerontine.Patients in study group were given with reduced glutathione on the basis of routine treatment.The therapeutic effect，liver function [alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，total bilirubin (TBiL)，γ-glutamyl endopeptidase (GGT)]，hepatic fibrosis [hyaluronidase (HA)，Ⅲ procollagen (PCⅢ)，Ⅳ collagen (Ⅳ-C)] and prothrombin time (PT) was compared and analyzed before and after treatment. Results The total effective rate in study group was 94.59%，higher than 70.27% in the control group，the difference was significant (P<0.05).After treatment，the ALT，AST，TBiL，GGT in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05).The HA，PCⅢ，Ⅳ-C in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05).PT in the two groups was decreased compared with before treatment (P<0.05)，and the study group was better than that of control group (P<0.05). Conclusion Reduced glutathione has excellent effect in treating alcoholic cirrhosis，it can improve the clinical symptom and the level of physiological indicators observably.
[Key words] Reduced glutathione；Alcoholic cirrhosis；Liver function；Therapeutic effect (吕福鸣)