来氟米特治疗风湿免疫性疾病的效果观察(1)
【摘要】 目的：探讨来氟米特治疗风湿免疫性疾病的效果。方法：选取2015年2月-2016年2月笔者所在医院收治的100例风湿免疫性疾病患者为研究对象，按照随机数字表法分为两组，每组50例。对照组采用单一激素治疗，来氟米特组采用激素联合来氟米特治疗。比较两组患者的病情缓解率；关节压痛消失时间、关节肿胀消失时间、晨僵持续时间、正常活动时间；干预前后患者血清尿酸、超敏C反应蛋白(hypersensitive C-reactive protein，hs-CRP)、血沉水平及晨僵时间；干预前后患者生存质量；脱发、肝肾损害、胃肠道损害等药物不良反应发生率。结果：来氟米特组患者病情缓解率高于对照组，差异有统计学意义(字2=6.016，P<0.05)；来氟米特组关节压痛消失时间、关节肿胀消失时间、晨僵持续时间短于对照组，正常活动时间早于对照组(t=8.202、9.824、10.724、12.162，P<0.05)。干预前两组血清尿酸、hs-CRP、血沉水平及平均晨僵时间比较，差异均无统计学意义(P>0.05)；干预后来氟米特组血清尿酸、hs-CRP、血沉水平及晨僵时间均短于对照组，差异均有统计学意义(P<0.05)。干预前两组生存质量评分比较，差异无统计学意义(t=0.624，P>0.05)；干预后来氟米特组生存质量评分显著高于对照组，差异有统计学意义(t=9.813，P<0.05)。两组患者的脱发、肝肾损害、胃肠道损害等药物不良反应发生率比较，差异无统计学意义(字2=0.000，P=1.000)。結论：来氟米特治疗风湿免疫性疾病的效果确切，可有效改善患者病情，促进血清学指标恢复，缓解临床症状，缩短晨僵时间，且不良反应少，安全性高，可有效改善患者生存质量，值得推广应用。
【关键词】 来氟米特； 风湿免疫性疾病； 效果
doi：10.14033/j.cnki.cfmr.2018.14.006 文献标识码 A 文章编号 1674-6805(2018)14-00-04
Effect of Leflunomide in the Treatment of Rheumatic Immune Diseases/CHEN Lizhen.//Chinese and Foreign Medical Research，2018，16(14)：16-19
【Abstract】 Objective：To investigate the effect of Leflunomide in the treatment of rheumatic diseases.Method：A total of 100 patients with rheumatic disease from February 2015 to February 2016 in our hospital were selected and divided into two groups according to the random number table method.The control group used a single hormone treatment，and the Leflunomide group used hormone combined with Leflunomide treatment.Compared two groups of rheumatic disease remission rate，joint pain disappeared time，joint swelling disappeared time，duration of morning stiffness，normal activity time；serum uric acid level，the level of hypersensitive C-reactive protein(hs-CRP)，erythrocyte sedimentation rate，the morning stiff time before and after the intervention，the quality of life scores of patients before and after the intervention，incidence of adverse reactions such as hair loss，liver and kidney damage，gastrointestinal tract damage.Result：The rheumatic disease remission rate of the Leflunomide group was higher than that of the control group，the difference was statistically significant(字2=6.016，P<0.05)，the joint pain disappeared time，joint swelling disappeared time，duration of morning stiffness，normal activity time were shorter than those of the control group，the differences were statistically significant(t=8.202，9.824，10.724，12.162，P<0.05).There was no significant difference in serum uric acid，hs-CRP，erythrocyte sedimentation level and morning stiff time between the two groups before intervention (P>0.05)，and the serum uric acid，hs-CRP，erythrocyte sedimentation level and morning stiff time in Leflunomide group were shorter than those in the control group，and the differences were statistically significant(P<0.05).There was no significant difference in the score of quality of life between the two groups before intervention(t=0.624，P>0.05).After intervention，the score of quality of life in Leflunomide group was significantly higher than that in the control group，the difference was statistically significant(t=9.813，P<0.05).The incidence of adverse reactions rate such as hair loss，damage to the liver and kidney，gastrointestinal damage had no significant differences in two groups(字2=0.000，P=1.000).Conclusion：Leflunomide in the treatment of rheumatic disease effect，can effectively improve the patients’ condition，promote the serological indexes returned to normal，alleviate the clinical symptoms，shorten the time of morning stiffness，and has less adverse reaction，high safety，can effectively improve the quality of life of patients.It is worthy of popularization and application., 百拇医药(陈丽珍)
【关键词】 来氟米特； 风湿免疫性疾病； 效果
doi：10.14033/j.cnki.cfmr.2018.14.006 文献标识码 A 文章编号 1674-6805(2018)14-00-04
Effect of Leflunomide in the Treatment of Rheumatic Immune Diseases/CHEN Lizhen.//Chinese and Foreign Medical Research，2018，16(14)：16-19
【Abstract】 Objective：To investigate the effect of Leflunomide in the treatment of rheumatic diseases.Method：A total of 100 patients with rheumatic disease from February 2015 to February 2016 in our hospital were selected and divided into two groups according to the random number table method.The control group used a single hormone treatment，and the Leflunomide group used hormone combined with Leflunomide treatment.Compared two groups of rheumatic disease remission rate，joint pain disappeared time，joint swelling disappeared time，duration of morning stiffness，normal activity time；serum uric acid level，the level of hypersensitive C-reactive protein(hs-CRP)，erythrocyte sedimentation rate，the morning stiff time before and after the intervention，the quality of life scores of patients before and after the intervention，incidence of adverse reactions such as hair loss，liver and kidney damage，gastrointestinal tract damage.Result：The rheumatic disease remission rate of the Leflunomide group was higher than that of the control group，the difference was statistically significant(字2=6.016，P<0.05)，the joint pain disappeared time，joint swelling disappeared time，duration of morning stiffness，normal activity time were shorter than those of the control group，the differences were statistically significant(t=8.202，9.824，10.724，12.162，P<0.05).There was no significant difference in serum uric acid，hs-CRP，erythrocyte sedimentation level and morning stiff time between the two groups before intervention (P>0.05)，and the serum uric acid，hs-CRP，erythrocyte sedimentation level and morning stiff time in Leflunomide group were shorter than those in the control group，and the differences were statistically significant(P<0.05).There was no significant difference in the score of quality of life between the two groups before intervention(t=0.624，P>0.05).After intervention，the score of quality of life in Leflunomide group was significantly higher than that in the control group，the difference was statistically significant(t=9.813，P<0.05).The incidence of adverse reactions rate such as hair loss，damage to the liver and kidney，gastrointestinal damage had no significant differences in two groups(字2=0.000，P=1.000).Conclusion：Leflunomide in the treatment of rheumatic disease effect，can effectively improve the patients’ condition，promote the serological indexes returned to normal，alleviate the clinical symptoms，shorten the time of morning stiffness，and has less adverse reaction，high safety，can effectively improve the quality of life of patients.It is worthy of popularization and application., 百拇医药(陈丽珍)