丹参多酚酸盐治疗冠心病心绞痛的临床疗效及安全性分析(1)
[摘要] 目的 探讨丹参多酚酸盐治疗冠心病心绞痛的临床疗效及安全性。 方法 将80例冠心病心绞痛患者按照入院先后随机分为对照组(n=40)与观察组(n=40)，两组均予血小板黏附聚集及稳定粥样斑块等常规治疗，观察组在此基础上静滴丹参多酚酸盐进行治疗。比较两组临床疗效、治疗后前生活质量及运动耐量、治疗前后心脏彩超所示左室结果指标水平、不良反应发生率。 结果 (1)经治疗，对照组临床总有效率为78.95%，显著低于观察组(92.86%)(P<0.05)；(2)两组治疗后，观察组患者生活质量评分明显优于对照组(P<0.05)，其6min步行距离差异亦具有统计学意义(P<0.05)；(3)治疗结束后，观察组患者左室射血分数(LVEF)明显优于对照组(P<0.05)，且其左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)及左房内径(LADd)亦显著小于对照组，且上述指标差异均具有统计学意义(P<0.05)；(4)对照组不良反应发生率为10.0%，观察组为7.5%，差异无统计学意义(P>0.05)。 结论 丹参多酚酸盐治疗冠心病心绞痛的临床疗效显著，可有效改善患者生活质量，不良反应发生率低，应在临床上进行推广。
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[关键词] 冠心病；心绞痛；丹参多酚酸盐；安全性
[中图分类号] R541.4 [文献标识码] B [文章编号] 2095-0616(2015)18-40-04
[Abstract] Objective To investigate the safety and the clinical efficacy of salvianolate in treating of angina pectoris. Methods 80 patients with angina pectoris were randomly divided into control group and observation group according to the suitable for admission。Firstly，the two groups were given antiplatelet adhesion，stability of atherosclerotic plaques and other conventional treatment。The observation group were given Salvia miltiorrhiza polyphenols acid salt on the basis of conventional treatment .The clinical curative effect， life quality and exercise tolerance， heart colour to exceed index and the incidence of adverse reactions were compared between the two groups. Results (1)After the treatment， the total effective rate of control group was 78.95%， was significantly lower than the observation group (92.86%) (P< 0.05). (2)The quality of life score and 6 min walking distance of observation group were better than the control group，the difference was significant between two groups(P<0.05). (3)After the treatment， the LVEF in the observation group was better than the control group (P<0.05).At the same time， the LVEDd， LVESd and LADd in the observation group were also significantly less than the control group， and the differences were significant (P<0.05) . (4)The incidence of adverse reactions of control group was 10.0%， and the observation group was 7.5%，There was no statistically significant difference between them (P>0.05). Conclusion Salvianolate in treating of angina pectoris has a good curative effect， and it can effectively improve the patients quality of life， reduce the incidence of adverse reactions， and it should be to promote in clinic.
[Key words] CHD； Angina pectoris； Salvia miltiorrhiza polyphenols acid salt； Safety
冠心病心绞痛是在冠脉狭窄的基础上，由于冠脉血流量显著小于心肌代谢所需的血流量，而导致心肌负荷量显著增大以及短暂性缺血缺氧所引发的[1]。冠心病心绞痛临床发作频率较高，如果对其不进行有效处理，那么极易导致急性心梗，更甚者则会出现死亡的情况[2]，故而应该高度关注此病的临床治疗方法。常规疗法以血小板黏附聚集及稳定粥样斑块等干预治疗为主，然而该方法的临床疗效一般，普遍存在患者满意度低下的情况[3]。本研究在此基础上联合丹参多酚酸盐对患者进行治疗，获得了非常满意的临床效果，现报道如下。, 百拇医药(曲爱民 张吉敏)
, http://www.100md.com
[关键词] 冠心病；心绞痛；丹参多酚酸盐；安全性
[中图分类号] R541.4 [文献标识码] B [文章编号] 2095-0616(2015)18-40-04
[Abstract] Objective To investigate the safety and the clinical efficacy of salvianolate in treating of angina pectoris. Methods 80 patients with angina pectoris were randomly divided into control group and observation group according to the suitable for admission。Firstly，the two groups were given antiplatelet adhesion，stability of atherosclerotic plaques and other conventional treatment。The observation group were given Salvia miltiorrhiza polyphenols acid salt on the basis of conventional treatment .The clinical curative effect， life quality and exercise tolerance， heart colour to exceed index and the incidence of adverse reactions were compared between the two groups. Results (1)After the treatment， the total effective rate of control group was 78.95%， was significantly lower than the observation group (92.86%) (P< 0.05). (2)The quality of life score and 6 min walking distance of observation group were better than the control group，the difference was significant between two groups(P<0.05). (3)After the treatment， the LVEF in the observation group was better than the control group (P<0.05).At the same time， the LVEDd， LVESd and LADd in the observation group were also significantly less than the control group， and the differences were significant (P<0.05) . (4)The incidence of adverse reactions of control group was 10.0%， and the observation group was 7.5%，There was no statistically significant difference between them (P>0.05). Conclusion Salvianolate in treating of angina pectoris has a good curative effect， and it can effectively improve the patients quality of life， reduce the incidence of adverse reactions， and it should be to promote in clinic.
[Key words] CHD； Angina pectoris； Salvia miltiorrhiza polyphenols acid salt； Safety
冠心病心绞痛是在冠脉狭窄的基础上，由于冠脉血流量显著小于心肌代谢所需的血流量，而导致心肌负荷量显著增大以及短暂性缺血缺氧所引发的[1]。冠心病心绞痛临床发作频率较高，如果对其不进行有效处理，那么极易导致急性心梗，更甚者则会出现死亡的情况[2]，故而应该高度关注此病的临床治疗方法。常规疗法以血小板黏附聚集及稳定粥样斑块等干预治疗为主，然而该方法的临床疗效一般，普遍存在患者满意度低下的情况[3]。本研究在此基础上联合丹参多酚酸盐对患者进行治疗，获得了非常满意的临床效果，现报道如下。, 百拇医药(曲爱民 张吉敏)